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Discovery Intern

ArcellxRockville, MdOnsite
This job is no longer open

Who We Are


Arcellx isa public, clinical-stage biotechnology company reimagining cell therapy by engineering innovative immunotherapies for patients with cancer and other incurable diseases. We believe that cell therapies are one of the forward pillars of medicine and our mission is to destroy cancer and advance humanity by developing cell therapies that are safer, more effective, and more broadly accessible. Our team members are made up of talented innovators and dreamers working from our offices in Rockville, Maryland, and Redwood City, California.

At Arcellx, we hire exceptional people and create a fun, diverse, supportive, and informal environment that allows everyone to do their best work. 

What Matters to Us


Living our core values is essential to maintaining a work environment that is high-performing, inclusive, and collaborative. We look for candidates who demonstrate strong values alignment and bring different backgrounds, viewpoints, and abilities to the team.Arcellx Core Values

  • Character: Committed to always doing what’s right. 
  • Audacity: Willing to challenge convention and share candid feedback with others.
  • Determination: Curious and self-motivated. Always looking to improve and learn.   
  • Collaboration: "No job is too small" mentality. Humble and willing to help others.
  • Originality: Will bring your unique perspective to the table and respect a diverse set of views and backgrounds. 

The “Fine Print” – What You’ll Do


  • Work with a team of scientists to developnovel protein-binding domains for use in Arcellx’s cancer cell therapy platforms.
  • Molecular cloning ofnovel binding domains into a variety of expression hosts (mammalian, lentiviral, yeast).
  • Flow cytometry and fluorescent-activated cell sorting (FACS) of novel binding domains expressed on the surface of yeast and mammalian cells.
  • Quantitative analysis of protein-protein interactions using Biolayer Interferometry (Octet) and ELISA.
  • Experience in a Unix/Linux command line computing environment and Python is highly preferred but not required.

Skills and Experience We Look For


  • Undergraduate or Master’s degree-level coursework covering the concepts behind immunotherapy, and cell therapy.
  • Preference given to prior wet lab experience in an academic research or industrial setting.
  • Familiarity with molecular biology methods, including primer design, PCR, gel electrophoresis, plasmid DNA preparation, cloning, and sequence analysis using SnapGene or similar.
  • Preferred knowledge of additional methods real-time PCR analysis, flow cytometry, and bioinformatics.

Join us in our quest to reimagine cell therapy and destroy cancer. For more on our technology, culture, and team, go to


www.arcellx.com


.


 #LI-Onsite

This job is no longer open

Life at Arcellx

Arcellx is a clinical-stage biopharmaceutical company developing novel, adaptive and controllable cell therapies for the treatment of patients with cancer and autoimmune diseases. The Company's proprietary ARC-sparX platform separates the tumor-recognition and tumor-killing functions of conventional CAR-T cell therapies: (1) sparX (soluble protein antigen-receptor X-linkers) proteins recognize and bind specific antigens on diseased cells and flag those cells for destruction; and (2) ARC-T (Antigen Receptor Complex-T) cells bind the sparX proteins and kill the flagged cells. Arcellx has developed a collection of sparX proteins that bind different cell surface antigens. Administration of alternate sparX proteins can redirect ARC-T cells to different disease antigens to potentially address relapsed and refractory disease due to tumor heterogeneity or antigen escape. Additionally, ARC-T cell activity can be curbed as needed by controlling the dose and frequency of sparX administration.
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