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Principal Scientist, Analytical Development

ArcellxOnsite
This job is no longer open

Who We Are


Arcellx isa public, clinical-stage biotechnology company reimagining cell therapy by engineering innovative immunotherapies for patients with cancer and other incurable diseases. We believe that cell therapies are one of the forward pillars of medicine and our mission is to destroy cancer and advance humanity by developing cell therapies that are safer, more effective, and more broadly accessible.Our team members are made up of talented innovators and dreamers working from our offices in Rockville, Maryland, and Redwood City, California.

At Arcellx, we hire exceptional people and create a fun, diverse, supportive, and informal environment that allows everyone to do their best work.

What Matters to Us


Living our core values is essential to maintaining a work environment that is high-performing, inclusive, and collaborative. We look for candidates who demonstrate strong values alignment and bring different backgrounds, viewpoints, and abilities to the team.Arcellx Core Values

  • Character: Committed to always doing what’s right.
  • Audacity: Willing to challenge convention and share candid feedback with others.
  • Determination: Curious and self-motivated. Always looking to improve and learn.  
  • Collaboration: "No job is too small" mentality. Humble and willing to help others.
  • Originality: Will bring your unique perspective to the table and respect a diverse set of views and backgrounds.

How You’ll Make a Difference


As a Principal Scientist in our Analytical Development group, you will have a direct impact on the Arcellx drug pipeline, both as a thought leader and a lab-based contributor. Our potentially life-saving treatments would not exist without the work of our talented scientists. Your work will have a direct impact on our ability to continue to deliver our transformative therapy to patients who need it most.

The “Fine Print” – What You’ll Do


  • Develop and optimize analytical methods to assess product identity, purity, potency and safety tests. 
  • Perform troubleshooting and evaluation of analytical methods such as molecular/ biological/ immuno-assays, including ddPCR, qPCR, ELISA, flow cytometry.
  • Participate in method transfers with CMOs.
  • Provide analytical support to process development and research and discovery teams.
  • Uses DOE and statistical methods to design effective experiments.
  • Thoroughly analyze results and methods, track/trend control data, solve analytical problems, and troubleshoot assays.
  • Author/ co-author and review reports, SOPs, and CMC documentation.

Skills and Experience We Look For


  • PhD. or master’s degree in immunology, cellular or molecular biology.
  • 8+ years (with PhD) or 12+ years (with MS) of industry experience in cancer drug development.
  • Expertise in analytical method development, characterization, and comparability assessment of cell and gene therapeutics.
  • Understanding of principles and practical applications of molecule-based assays, flow cytometry, cell enumeration and viability.
  • Excellent organizational and prioritization skills with an ability to deliver results within aggressive timelines.
  • Demonstrates strong analytical and problem-solving skills.
  • Exceptional collaboration, communication, and interpersonal skills.

Rewards at Arcellx


Our people are our greatest asset, and supporting their well-being is an essential part of delivering on our mission and impacting the lives of patients. Putting this belief into practice means offering strong compensation and benefits.In addition to a competitive base salary, our compensation package includes an annual bonus based on company goals and an equity (RSU) grant. We do offer relocation assistance for roles if required.Our market-leading benefits package includes: 100% coverage for medical, dental and vision for team members and dependents, unlimited vacation, a 3-day weekend every month, fully-paid parental leave for up to 6 months, tuition reimbursement, 401k employer contribution and more. 

Join us in our quest to reimagine cell therapy and destroy cancer. For more on our technology, culture, and team, go to


www.arcellx.com


.


 #LI-Onsite

This job is no longer open

Life at Arcellx

Arcellx is a clinical-stage biopharmaceutical company developing novel, adaptive and controllable cell therapies for the treatment of patients with cancer and autoimmune diseases. The Company's proprietary ARC-sparX platform separates the tumor-recognition and tumor-killing functions of conventional CAR-T cell therapies: (1) sparX (soluble protein antigen-receptor X-linkers) proteins recognize and bind specific antigens on diseased cells and flag those cells for destruction; and (2) ARC-T (Antigen Receptor Complex-T) cells bind the sparX proteins and kill the flagged cells. Arcellx has developed a collection of sparX proteins that bind different cell surface antigens. Administration of alternate sparX proteins can redirect ARC-T cells to different disease antigens to potentially address relapsed and refractory disease due to tumor heterogeneity or antigen escape. Additionally, ARC-T cell activity can be curbed as needed by controlling the dose and frequency of sparX administration.
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