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Building formulation capabilities for mRNA design validation

InceptiveVancouver, British Columbia, CanadaOnsite
This job is no longer open

At Inceptive, we don't have titles. Instead of topic experts working in silos, we are building an
antedisciplinary team where everyone is gaining deep knowledge outside of their traditional area of expertise. For this reason, we call ourselves Beginners.OverviewAt Inceptive, you will drive development forward that could help billions of people. To accomplish this, you will be part of a collaborative, antedisciplinary team building our biological software.Lipid nanoparticles (LNPs) currently serve as the primary delivery vehicle for mRNA-based therapeutics and are required for obtaining high-quality in vivo data.

Your work will enable us to formulate mRNA designs into LNPs with the goal of enabling us to better understand and model the performance of our mRNA designs within in vivo settings. In addition, you will be responsible for maintaining detailed notes and developing standard operating procedures while ensuring high-quality data acquisition.Your mission, should you choose to accept it

  • Develop and implement methodologies for the formulation of mRNAs into various lipid nanoparticles using traditional and innovative methods
  • Embody our vision of an antedisciplinary environment and embrace learning outside of your traditional area of expertise
  • Collaborate with team members from diverse backgrounds to build innovative and scalable experiments to solve complex problems that span biology and computation

Minimum Qualifications

  • PhD, or Post-doctoral experience, or 4+ years of industry experience in biochemistry, drug formulation, or nanoparticles
  • Expertise in the theoretical and practical formulation of lipid nanoparticles and other drug delivery modalities
  • Expertise with instrumentation required for formulation (i.e. T-junction mixing, microfluidics, etc.)
  • Problem-solver who is equally excited by finding creative solutions to complex problems as you are by executing them
  • Ability to communicate technical and scientific concepts to team members from a broad variety of backgrounds
  • Availability to accommodate working with team members across different time zones, with one or two meetings per week starting at 8am PT or finishing at 7pm CET
  • Readiness to travel several times a year for company retreats and business events
  • We value the benefits of in-person collaboration and expect candidates to primarily work at our office locations

Preferred Technical Skills

  • Solid foundation in molecular and cellular biology (RNA biology is a plus)
  • A deep understanding of lipid nanoparticle biology and biochemistry (e.g. lipid chemistries, LNP-cell interactions and distributions, methods to study LNP biology)
  • Expertise in the characterization of nanoparticles (e.g. dynamic light scattering, size-exclusion chromatography, qRT-PCR) and stability studies
  • Experience with in vivo systems and experimental study design

Compensation$180K – $265K CAD + Bonus + EquityWhat we offer

  • A competitive compensation package
  • 30 days paid vacation per year
  • Comprehensive health insurance and 401K with company match (US) or comparable benefits if based in other countries
  • Quarterly company-wide retreats
  • Budget for multiple visits per year to our offices in Berlin and/or in Palo Alto
  • Learning & Development budget to attend conferences, take courses, or otherwise invest in your professional growth, as well as access to the Learning & Development platform EdX
  • A buddy to help you get settled

About InceptiveAt Inceptive, we are creating tools to develop increasingly powerful biological software for the rational design of novel, broadly accessible medicines and biotechnologies previously out of reach. Our team brings together vast expertise in molecular biology, machine learning, and software engineering, and we are all working towards becoming antedisciplinary, meaning we deepen the knowledge we have in our area of expertise while also expanding our knowledge of completely new fields.We approach our goals with a beginner's mind, humbly and with fresh eyes, and aim to become the pioneers of a new discipline rooted in biology as much as in deep learning, whose impact will be realized together with out-of-the-box thinkers in business and entrepreneurship, defying established categorizations.

We are building a company culture centered around growth, learning, and discovery. We believe in humility and open-mindedness in how we approach each other, as well as problems we don't yet have solutions for.It is the policy of Inceptive to ensure equal employment opportunity without discrimination or harassment on the basis of race, color, religion, sex, sexual orientation, gender identity or expression, age, disability, marital status, citizenship, national origin, genetic information, or any other characteristic protected by law.

Inceptive prohibits any such discrimination or harassment.Inceptive is also committed to welcoming and providing accommodations to people with disabilities. Please let your recruiter know if you need any accommodations throughout your application process.

This job is no longer open

Life at Inceptive

RNA therapeutics and vaccines are transforming the world. To unlock their full potential, however, we need molecules with properties and functions that are impossible to design with existing methods. Inceptive is enabling the design of this next generation of RNA molecules through a singular combination of highly scalable experiments and deep learning.We are led by world-renowned experts in RNA biochemistry and deep learning who contributed to breakthroughs in problems ranging from RNA structure modeling to language understanding, computer vision and machine learning for science. We are growing our world-class team of scientists, computational researchers, engineers, and entrepreneurs excited to learn, teach, invent, and create together in pursuit of learning life’s languages to improve the lives of billions of people around the world.
Thrive Here & What We Value1. Antedisciplinary Environment2. Emphasis on Learning and Discovery3. Growth-Oriented Culture4. OpenMindedness and Humility in Approach to Problems5. Collaborative Team Building6. Commitment to Equal Employment Opportunity and Accommodations for People with Disabilities7. Innovation and Discovery Focus8. Professional Development Support
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