Adverum is a clinical stage AAV-based gene therapy company targeting unmet medical needs in ocular and rare diseases. We are seeking a highly motivated and collaborative Research Associate/Associate Scientist with experience in ocular biology to join our team in our Redwood City office. The successful candidate will play a critical role in the development and optimization of Adverum’s gene therapy pipeline of products. This individual will work in a cross-functional team to support the research and development of novel vector technologies and IND-enabling studies.
What you'll do:
- · Support the execution of assays for discovery and translational research. Assay read-outs include ELISA, qPCR, FACS, SDS-PAGE, agarose gels, western blot, and flow cytometry.
- · Produce, purify, and characterize complex biological molecules like DNA, RNA, protein, and AAV.
- · Maintenance, transfection and transduction of different cell types.
- · Perform sample processing from a variety of tissue types.
- · Order and maintain sufficient inventory of materials and reagents for planned laboratory activities.
- · Perform routine lab maintenance.
- · Follow established protocols and SOPs.
- · Ensure accurate laboratory records and project updates.
- · Participate in team meetings and present technical data.
- · Must be comfortable in a fast-paced, small company environment.
- · Be involved with development, qualification, and transfer of bioanalytical methods to support preclinical and clinical assays
- · Other responsibilities may be assigned as needed.
About you:
- Minimum of a biological science or similar Bachelor’s degree with 6-8 years of relevant experience in a biotech company, or a Master’s degree with 4-5 years of relevant experience, or an equivalent combination of education and experience.
- Proficient in a variety of molecular biology techniques such as recombinant DNA technology, cloning, isolation/analysis of nucleic acids, PCR, RT-PCR, and qPCR is required.
- Expertise in sterile tissue culture techniques including transfection, transduction, developing and maintaining cell lines is a must.
- Hands-on experience with the execution of bioassays using technologies including ddPCR, ELISA, MSD, Luminex, flow cytometry and cell-based potency assays are advantageous.
- Experienced in sample processing methods to support protein and nucleic acid detection from a variety of animal/human tissues.
- Experience with other analytical methods of gene expression and protein detection is advantageous.
- ·Background and understanding of AAV biology and ocular biology are preferable.
- ·Experienced with data analysis software like GraphPad Prism, FlowJo, SoftMax Pro, and Geneious Prime.
- Demonstrated ability to effectively work independently as well as in a team-oriented environment.
- ·Well organized and able to multitask with attention to detail while maintaining electronic notebook and accurate records.
- ·Excellent verbal and written communication skills. Ability to interpret, summarize, and present scientific results to both technical and non-technical audiences.
$25 - $65 an hourHourly depends on experience Adverum is a clinical-stage gene therapy company targeting unmet medical needs in ophthalmology and rare diseases. Adverum develops gene therapy product candidates designed to provide durable efficacy by inducing sustained expression of a therapeutic protein. Adverum’s core capabilities include clinical development, novel vector discovery and in-house manufacturing expertise, specifically in scalable process development, assay development, and current Good Manufacturing Practices quality control.At Adverum, Inclusion and Diversity are at our core.
We believe in the power of being your authentic self. We strive to create the space which allows for everyone in our Adverum Community to not only feel safe but encouraged to speak, learn from each other, grow in their professions and be the very best versions of themselves no matter what their age, ethnic background, gender, origin, religion or sexual orientation.Apply for this job
