Adverum is looking for a Pilot Plant Associate, Candidate Process Development to join the Candidate Process Development team at our Redwood City, CA office. The individual will be responsible for executing large scale rAAV production and expansion processes and procedures that enable downstream workflows in the team. This position will interact cross-functionally with Assay Development, Quality Control, and pre-Clinical team (Research & Non-Clinical), as well as across the organization to enable Adverum success.
What you'll do:
- Execute pilot-scale bioreactor runs according to established protocols and procedures.
- Prepare and manage bioreactor systems, media, and solutions.
- Perform cell culture inoculation, monitoring, and sampling during bioreactor runs.
- Monitor and control critical process parameters to ensure optimal cell growth and product expression.
- Troubleshoot deviations process and implement corrective actions as needed.
- Collaborate with cross-functional teams to analyze and interpret process data.
- Document experimental procedures, results, and observations in laboratory notebooks and reports.
- Work with cross-functional teams to generate material and coordinate testing.
- Maintain a clean and organized laboratory environment and adhere to safety guidelines and regulations.
About you:
- Requires a Bachelor’s degree (or higher) in chemical/biochemical engineering or related fields.
- Minimum of 4 years of hands-on experience in upstream cell culture process development and optimization, preferably in gene therapy.
- Proficiency in operating and troubleshooting large-scale bioreactor systems, with a strong understanding of bioprocess engineering principles and practices.
- Experience working with insect cell lines (e.g., Sf9) and viral vector production is highly desirable.
- Experience with statistical analysis software (e.g., JMP) and data visualization tools.
- Excellent communication and teamwork skills, with the ability to collaborate effectively across functional teams.
- Detail-oriented with strong problem-solving abilities and a proactive approach to challenges.
- Familiarity with regulatory guidelines and requirements for biologics manufacturing is a plus.
- Some overtime required, as needed.
$30 - $45 an hourThis is a contract hourly position.Apply for this job
