Take a Look at Your Future with Crown Bioscience
A path towards your most rewarding career. Our mission is to address the unmet needs in life science by creating and supplying innovative translational technologies and platforms. Our products and services have been profoundly expediting research for in vitro, in vivo, translational oncology, target validation, preclinical proof of concept, assistive clinical strategy design, and biomarker discovery.Pharmacokinetic is a science that studies the mechanism of the body's action on drugs. It employs kinetic principles and mathematical models to quantitatively describe and summarize the Absorption, Distribution, Metabolism and Elimination of drugs through various pathways.
That is, the dynamic law of "dose-time" change or "time-dependent blood drug concentration" change in ADME process.
PRIMARY RESPONSIBILITIES
- Lead or design, conduct and report in vitro ADME studies (absorption, distribution, metabolism and excretion) including assay designs, LC-MS/MS or LC-HRMS based bioanalytical method development, sample generation and sample analysis, data analysis, interpretation and reporting.
- Develop new in vitro ADME assays as needed to address specific project or study issues, or new service capability.
- Serves as a DMPK representative on discovery and preclinical programs and initiatives; performing CYP450 and transporter mediated drug-drug interaction potential and Met-ID and in vitro - in vivo correlation analysis, ADME data interpretation and application.
- Manage and supervise an in vitro ADME group; and collaborate with various functional DMPK groups,
- Communicate effectively with clients for study update, project management and technical support.
- Keeps up to date with emerging new mass spectrometric technologies, ADME assays such as transporters and regulatory technical guidelines.
- Possess good interpersonal, oral and written communication skills.
EDUCATION AND EXPERIENCE
- A M.S. or Ph.D. degree in drug metabolism, pharmaceutical science, organic chemistry, analytical chemistry, biochemistry, or related discipline with 3 - 10 years’ experience in pharmaceutical and biotechnological companies, or contract research organizations.
SKILL REQUIREMENTS
- Hands-on experience in designing, conducting, analyzing and reporting in vitro ADME studies, including study designs, bioanalytical method development, sample generation and analysis, data analysis and reporting to support drug discovery and preclinical projects.
- Working experience in quantitative LC-MS/MS method development and sample analysis with AB Sciex API LC-MS/MS and other vendors’ mass spectrometry systems (Thermo high resolution mass spectrometry QE plus or OE240); experience with high throughput autosamplers and programming automated liquid handlers.
- Familiar with IND-enabling in vitro ADME studies to support regulatory filing (China NMPA, US FDA, EMA).
- Good command of office software like word, excel and PPT.
- Strong learning and hands-on ability
OUR OFFER
- Competitive remuneration + target bonus + allowance
- 5 days per week (8h working hour)
- Paid annual leave
- Work-Life Balance
- Festival gift and allowance
- Supplemental Medical insurance
- Social insurance and housing insurance
WHY JOIN US?
If you love the intellectual challenge of working in a fast-paced, results-driven organization, there is a home for you at Crown Bioscience. Those who join Crown Bioscience feel a sense of ownership about their future. They thrive through innovation in the foremost fields in biotechnology. Here, you will join passionate professionals who strive to develop innovative products and technologies for biopharmaceutical applications to advance fields in science and medicine. You will excel in an environment characterized by respect, integrity, and growth opportunities.To find out more about global job opportunity, where you can take a look at your future with Crown Bioscience.
About Crown Bioscience
Crown Bioscience, a JSR Life Sciences company, is a global Contract Research Organization (CRO) partnering with biotech and pharmaceutical companies to rapidly advance the discovery and development of oncology drugs. As the exclusive preclinical CRO providing tumor organoid services with the well-established Hubrecht Organoid Technology, we offer over 600 organoid models spanning 22 cancer indications. Furthermore, we have developed the world’s largest commercially available PDX collection. Our focus on helping our customers develop novel therapies aims to ensure that patients receive the right treatment at the right time.
Founded in 2006, we have 13 facilities across the US, Europe, and Asia. For more information, visit: https://www.crownbio.com
