Earli exists to make cancer a benign experience. Earli does that by turning cancers against themselves: genetically
forcing them to reveal themselves early, and then kill themselves – precisely and clearly distinguishable from benign lesions at early stages. Based on original technology from Stanford’s renowned Gambhir lab, Earli designs genetic constructs that are injected intravenously that turn cancer cells against themselves. These programmable synthetic promoter-reporter sequences “flip on” like light switches only in dysregulated cancer cells and turn them into "factories." The cancer is forced to produce either an epitope “docking station” for imaging agents, or a cytokine for immune system activation against the tumor.
Thus, Earli’s platform enables immediate diagnosis and treatment of early cancers, rather than long-term observation that can lead to deadly metastatic recurrence.Earli's synthetic target expression platform has evolved over five years of deep bioengineering. The system can now detect broad ranges of patient mutations, distinguish between malignant and benign lesions, and offer independence from often elusive natural biomarkers.
Who You Are
- You share our same sense of dedication, scientific passion and entrepreneurial spirit
- You work well in a fast-paced and extremely focused startup environment
- You are not only smart, but clever and constantly think outside the box
- You are able to make logical decisions in an instant when there is little time to evaluate
- You are a natural communicator and relationship builder
- You stay calm under high pressure and stress
- You have the ability to multi-task in a serious way, with an extreme attention to detail
- You become a representative of the core DNA of the company through who you are
The Position
Earli, Inc. is currently seeking a highly motivated and committed Associate Scientist to join our in vivo pharmacology team. This position reports to the Associate Principal Scientist of Translational Biology.
Your Primary Responsibilities
Earli’s platform technology uses cancer-activated gene expression to usurp the dysregulated pathways that lead to malignancy. We are leveraging this platform for the creation of novel immuno-oncology therapeutic approaches to treat cancer. Your work will directly support the in vivo evaluation of these approaches. Within this context, you will:
- Conduct, plan, perform, and analyze rodent in vivo experiments testing our cancer treatment products
- Administer test agents to mice via multiple routes (IV, PO, IP, SC)
- Assess tumor burden by caliper, bioluminescence, fluorescence and microCT measurements
- Conduct rodent blood collections, surgeries, and necropsies
- Contribute to Biochemical/Molecular analysis of tissues and plasma (i.e. qPCR, Luminex)
- Maintain familiarity with current scientific literature
- Depending on the level of experience, the candidate would be encouraged to lead their own projects and presenting data both internally and at conferences
- Work independently and collaborate with scientific colleagues in support of team goals
Your Required Experience, Knowledge and Skill
- Minimum of 3+ years of industry experience conducting rodent studies to determine efficacy of new therapies
- Must have technical expertise in mouse handling, IV dosing, subcutaneous and orthotopic tumor cell implantation, tissue collection
- Experience in contributing to cancer research questions is an advantage
- Experience with biochemical and/or molecular techniques is an advantage
- Strong communication skills are required
- Strong sense of scientific rigor, integrity, and curiosity are required
- Ability to handle multiple projects simultaneously and meet aggressive project timelines
- Highly organized with reliable time management skills
- Ability to maintain detailed documentation
- Ability to work in a team-oriented and fast-paced environment
- Proficient with basic computer programs routinely used in a lab such as MS Word, Excel, and PowerPoint, GraphPad Prism
The base salary for this position is $90k-$110k per year.If interested in applying, please attach a CV or have a well-developed LinkedIn profile for us to be able to assess your background. We look forward to hearing from you!
