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Senior/Staff Machine Learning Engineer

Dyno TherapeuticsWatertown | Massachusetts, United StatesOnsite

The Role


Senior/Staff Machine Learning Engineer. As a Machine Learning Engineer at Dyno Therapeutics, you will work with Machine Learning researchers to advance modeling efforts and build scalable tools for machine learning and infrastructure. You will play a key role in driving the direction of ML research infrastructure, accelerating research with your expertise, and developing flexible, high-performance systems.Job Type: Full TimeLocation: Watertown, MA or NYC (may consider remote candidates)

How You Will Contribute


As a Senior/Staff Machine Learning Engineer, you will accelerate research by collaborating on modeling efforts, building tools and data pipelines that improve the team’s efficiency, and driving the future direction of the ML infrastructure at Dyno. Responsibilities: 

  • Collaborate with ML scientists and engineers to understand their needs and translate them into effective tools and systems that accelerate ML research.
  • Manage ML infrastructure, including configuring and maintaining GPU compute resources.
  • Design, develop, and maintain scalable data pipelines for ML data from external (PDB, UniProt, etc.) and internal sources.
  • Develop, deploy, and monitor deep learning models built primarily using PyTorch but potentially other frameworks (e.g. Jax).
  • Work with SQL and NoSQL databases for efficient data retrieval, storage, and analysis.
  • Conduct unit testing, code reviews, and follow software design principles to ensure high-quality code.
  • Stay current with emerging ML techniques, tools, and trends, and apply them to improve systems and workflows.

Basic qualifications


  • 3+ years of post-graduate, full time work experience in industry.
  • Strong foundation in software engineering with proficiency in programming languages such as Python.
  • Experience building data systems to support machine learning, including data processing libraries such as Pandas and NumPy.
  • Proficiency in SQL and NoSQL databases for data retrieval and storage.
  • Experience deploying and developing deep learning models using frameworks like PyTorch, Jax, Keras, or Tensorflow.
  • Familiarity with MLOps systems for training, monitoring, and evaluating ML models.
  • Experience building cloud-native systems and infrastructure, with an understanding of the benefits of GPU compute.
  • Alignment with Dyno’s core values.

Preferred qualifications


  • Experience handling large datasets using platforms like Apache Spark or Hadoop.
  • Experience managing GPU compute infrastructure.
  • Previous experience in a machine learning and biology-focused company.

The Company


At Dyno Therapeutics, we are a forward-thinking team on a mission to build high-performance genetic technologies that transform patient lives. Our team unites world-class molecular biologists, protein engineers, software developers, data scientists, and machine learning experts—all working together to shape the future of gene therapy.Our culture is defined by three core values:

  • One Mission: Everything we do is for the mission. We are a cohesive and motivated team, thinking ahead and supporting one another to overcome challenges.
  • Proactive Responsibility: We take action, inject energy into our work, and hold ourselves accountable for delivering results.
  • Reaching for Excellence: We constantly strive for excellence, fueled by curiosity, adaptability, and the courage to speak hard truths in pursuit of success.

These values are more than words—they guide our daily actions. We seek individuals who share our passion for innovation, excellence, and teamwork. At Dyno, building life-changing technologies isn’t just a job; it’s a mission that drives us forward.

Equal Employment Opportunity (EEO) Statement


We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Fraud Alert:

 Please be aware of recruitment scams targeting job seekers. Dyno Therapeutics will never make an offer of employment without conducting a formal interview process, nor will we ask for personal information such as financial details over email. Official communication will only come from an @dynotx.com email address. If you are contacted by someone claiming to represent Dyno Therapeutics from any other domain, please report it as spam and report the communication to us at jobs@dynotx.com.

Life at Dyno Therapeutics

Dyno Therapeutics is a Cambridge based, VC-backed biotech startup that uses next-gen DNA technologies and machine learning to engineer Adeno-associated Virus (AAV) capsids for effective delivery of gene therapies.
Thrive Here & What We Value- Pioneer in machine learning for blackbox protein design- Values diversity; non-discriminatory policies- NEVY Emerging Company of the Year (2021)- Endpoints 11 Company (2021)- Forbes' America’s Best Startups (2022, 2023)

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